Activation and manipulation of inflammasomes and pyroptosis during bacterial infections.
Biochem J
; 479(7): 867-882, 2022 04 14.
Article
en En
| MEDLINE
| ID: mdl-35438136
ABSTRACT
Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy. The initiation of pro-inflammatory, lytic pyroptosis is controlled by inflammasomes, which respond to a range of cellular perturbations. As is true for many host defence pathways, pathogens have evolved multiple mechanisms to subvert this pathway, many of which have only recently been described. Herein, we will discuss the mechanisms by which inflammasomes sense pathogen invasion and initiate pyroptosis and the effector mechanisms used by pathogens to suppress this pathway and preserve their niche.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Bacterianas
/
Piroptosis
Límite:
Humans
Idioma:
En
Revista:
Biochem J
Año:
2022
Tipo del documento:
Article
País de afiliación:
Suiza