Trimethyl chitosan postoperative irrigation solution modulates inflammatory cytokines related to adhesion formation.
Carbohydr Polym
; 288: 119380, 2022 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-35450642
ABSTRACT
Lavage or irrigation has been instilled in surgical practice for wound clearance and surgical site infection prevention during and after surgery. Herein, we developed a new irrigation solution using trimethyl chitosan (TMC), a quaternized chitosan derivative. The TMC-saline irrigation solution developed in the study possesses highly effective bactericidal properties with hemostatic and anti-adhesion properties. The anti-adhesion property of TMC was investigated in relation to inflammatory cytokine response and wound healing. TMC-saline irrigation solution showed reduced pro-inflammatory cytokine protein and gene expressions relevant in the cascade of wound healing and cytokine-related orchestration of postoperative adhesion formation. Further development of this multifunctional TMC-saline irrigation solution can be beneficial for surgical applications and postoperative wound management.
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Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quitosano
Idioma:
En
Revista:
Carbohydr Polym
Año:
2022
Tipo del documento:
Article