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Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
Müller-Eigner, Annika; Sanz-Moreno, Adrián; de-Diego, Irene; Venkatasubramani, Anuroop Venkateswaran; Langhammer, Martina; Gerlini, Raffaele; Rathkolb, Birgit; Aguilar-Pimentel, Antonio; Klein-Rodewald, Tanja; Calzada-Wack, Julia; Becker, Lore; Palma-Vera, Sergio; Gille, Benedikt; Forne, Ignasi; Imhof, Axel; Meng, Chen; Ludwig, Christina; Koch, Franziska; Heiker, John T; Kuhla, Angela; Caton, Vanessa; Brenmoehl, Julia; Reyer, Henry; Schoen, Jennifer; Fuchs, Helmut; Gailus-Durner, Valerie; Hoeflich, Andreas; de Angelis, Martin Hrabe; Peleg, Shahaf.
Afiliación
  • Müller-Eigner A; Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Sanz-Moreno A; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • de-Diego I; Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Venkatasubramani AV; Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University, 82152, Planegg-Martinsried, Germany.
  • Langhammer M; Institute Genetics and Biometry, Lab Animal Facility, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Gerlini R; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Rathkolb B; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
  • Aguilar-Pimentel A; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Klein-Rodewald T; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
  • Calzada-Wack J; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, 81377, Munich, Germany.
  • Becker L; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Palma-Vera S; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Gille B; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Forne I; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
  • Imhof A; Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Meng C; Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Ludwig C; Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University, 82152, Planegg-Martinsried, Germany.
  • Koch F; Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University, 82152, Planegg-Martinsried, Germany.
  • Heiker JT; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, 85354, Freising, Germany.
  • Kuhla A; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, 85354, Freising, Germany.
  • Caton V; Institute of Nutritional Physiology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Brenmoehl J; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
  • Reyer H; Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.
  • Schoen J; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Fuchs H; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Gailus-Durner V; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • Hoeflich A; Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
  • de Angelis MH; Department of Reproduction Biology, Leibniz Institute for Zoo and Wildlife Research (IZW), Berlin, Germany.
  • Peleg S; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), 85764, Neuherberg, Germany.
Commun Biol ; 5(1): 408, 2022 05 03.
Article en En | MEDLINE | ID: mdl-35505192
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Indicadores de Calidad de la Atención de Salud / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Commun Biol Año: 2022 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Indicadores de Calidad de la Atención de Salud / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Commun Biol Año: 2022 Tipo del documento: Article País de afiliación: Alemania