The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study.

Penjisevic, Jelena Z; Sukalovic, Vladimir B; Andric, Deana B; Surucic, Relja; Kostic-Rajacic, Sladjana V

Penjisevic, Jelena Z; Sukalovic, Vladimir B; Andric, Deana B; Surucic, Relja; Kostic-Rajacic, Sladjana V.

Afiliación

Penjisevic JZ; ICTM-Department of Chemistry, University of Belgrade, Njegoseva 12, 11000, Belgrade, Serbia.
Sukalovic VB; ICTM-Department of Chemistry, University of Belgrade, Njegoseva 12, 11000, Belgrade, Serbia.
Andric DB; Faculty of Chemistry, Department of Organic Chemistry, University of Belgrade, Studentski trg 12-16, 11158, Belgrade, Serbia. deanad@chem.bg.ac.rs.
Surucic R; Faculty of Medicine, Department of Pharmacognosy, University of Banja Luka, Save Mrkalja 14, 78000, Banja Luka, Bosnia and Herzegovina.
Kostic-Rajacic SV; ICTM-Department of Chemistry, University of Belgrade, Njegoseva 12, 11000, Belgrade, Serbia.

Appl Biochem Biotechnol ; 194(8): 3749-3764, 2022 Aug.

Article en En | MEDLINE | ID: mdl-35507251

Asunto(s)

Imidazoles; Animales; Humanos; Ligandos; Masculino

Palabras clave

Alpha1-adrenergic receptors; Arylpiperazines; Binding assay; Docking analyses; Molecular dynamics simulations; Pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Imidazoles Límite: Animals / Humans / Male Idioma: En Revista: Appl Biochem Biotechnol Año: 2022 Tipo del documento: Article

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