ß-Glucan-Functionalized Mesoporous Silica Nanoparticles for Smart Control of Fungicide Release and Translocation in Plants.

ABSTRACT

In this work, an enzyme-responsive nanovehicle for improving captan (CAP) contact fungicide bioactivity and translocation in plant tissues was synthesized (CAP-MSNs-ß-glucan) by attaching ß-glucan to the outer surface of mesoporous silica nanoparticles. CAP-MSNs-ß-glucan properties were tested by FTIR, ζ-potential, DLS, XRD, TGA, FE-SEM, and HR-TEM. Cargo protection ability of CAP-MSNs-ß-glucan from photolysis and hydrolysis was examined in comparison to CAP commercial formulation (CAP-CF). CAP-MSNs-ß-glucan distribution in plant tissues, bioactivity against Fusarium graminearum, and biotoxicity toward zebrafish (Danio rerio) were tested and compared with that of CAP-CF. CAP-MSNs-ß-glucan results showed good loading efficacy reaching 18.39% and enzymatic-release dependency up to 83.8% of the total cargo after 20 days of ß-glucan unsealing. CAP-MSNs-ß-glucan showed significant release protection under pH changes. MSNs-ß-glucan showed excellent CAP protection from UV. CAP-MSNs-ß-glucan showed better distribution in corn tissues and 1.28 more inhibiting potency to Fusarium graminearum than CAP-CF. CAP-MSNs-ß-glucan showed 1.88 times lower toxicity than CAP-CF to zebrafish after 96 h of treatment. We recommend using such formulations to overcome shortcomings of contact fungicides and achieve better and sustainable farming.