SK119, a Novel Shikonin Derivative, Leads to Apoptosis in Melanoma Cell Lines and Exhibits Synergistic Effects with Vemurafenib and Cobimetinib.

Kretschmer, Nadine; Durchschein, Christin; Hufner, Antje; Rinner, Beate; Lohberger, Birgit; Bauer, Rudolf

Kretschmer, Nadine; Durchschein, Christin; Hufner, Antje; Rinner, Beate; Lohberger, Birgit; Bauer, Rudolf.

Afiliación

Kretschmer N; Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Durchschein C; Division of Biomedical Research, Medical University Graz, Roseggerweg 48, 8036 Graz, Austria.
Hufner A; Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Beethovenstr. 8, 8010 Graz, Austria.
Rinner B; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.
Lohberger B; Division of Biomedical Research, Medical University Graz, Roseggerweg 48, 8036 Graz, Austria.
Bauer R; Department of Orthopedics and Trauma, Medical University Graz, Auenbruggerplatz 5, 8036 Graz, Austria.

Int J Mol Sci ; 23(10)2022 May 19.

Article en En | MEDLINE | ID: mdl-35628494

Asunto(s)

Melanoma; Neoplasias Cutáneas; Apoptosis; Azetidinas; Línea Celular; Humanos; Melanoma/metabolismo; Naftoquinonas; Piperidinas; Proteínas Proto-Oncogénicas B-raf/genética; Neoplasias Cutáneas/genética; Vemurafenib/farmacología; Vemurafenib/uso terapéutico

Palabras clave

apoptosis; melanoma; shikonin; shikonin dimer; synergism; vemurafenib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Austria

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