Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative.

Zhao, Ruiming; Shen, Rong; Dai, Hui; Perozo, Eduardo; Goldstein, Steve A N

Zhao, Ruiming; Shen, Rong; Dai, Hui; Perozo, Eduardo; Goldstein, Steve A N.

Afiliación

Zhao R; Department of Physiology and Biophysics, School of Medicine, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697.
Shen R; Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, IL 60637.
Dai H; Department of Physiology and Biophysics, School of Medicine, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697.
Perozo E; Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, IL 60637.
Goldstein SAN; Department of Physiology and Biophysics, School of Medicine, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697.

Proc Natl Acad Sci U S A ; 119(23): e2120750119, 2022 06 07.

Article en En | MEDLINE | ID: mdl-35648818

Asunto(s)

Diseño de Fármacos; Canales Iónicos; Humanos; Canales Iónicos/antagonistas & inhibidores; Canales Iónicos/química; Canales Iónicos/genética; Masculino; Mutagénesis; Péptidos/química; Péptidos/farmacología; Unión Proteica; Protones; Capacitación Espermática

Palabras clave

C6; bivalent toxin; molecular dynamics simulations; tethered toxin; voltage-gated proton channel

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Canales Iónicos Límite: Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article

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