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New Views of Old Proteins: Clarifying the Enigmatic Proteome.
Burnum-Johnson, Kristin E; Conrads, Thomas P; Drake, Richard R; Herr, Amy E; Iyengar, Ravi; Kelly, Ryan T; Lundberg, Emma; MacCoss, Michael J; Naba, Alexandra; Nolan, Garry P; Pevzner, Pavel A; Rodland, Karin D; Sechi, Salvatore; Slavov, Nikolai; Spraggins, Jeffrey M; Van Eyk, Jennifer E; Vidal, Marc; Vogel, Christine; Walt, David R; Kelleher, Neil L.
Afiliación
  • Burnum-Johnson KE; The Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA. Electronic address: kristin.burnum-johnson@pnnl.gov.
  • Conrads TP; Inova Women's Service Line, Inova Health System, Falls Church, Virginia, USA.
  • Drake RR; Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA.
  • Herr AE; Department of Bioengineering, University of California, Berkeley, California, USA.
  • Iyengar R; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Kelly RT; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
  • Lundberg E; Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
  • MacCoss MJ; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • Naba A; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA.
  • Nolan GP; Department of Pathology, Stanford University, Stanford, California, USA.
  • Pevzner PA; Department of Computer Science and Engineering, University of California at San Diego, San Diego, California, USA.
  • Rodland KD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
  • Sechi S; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Slavov N; Department of Bioengineering, Northeastern University, Boston, Massachusetts, USA.
  • Spraggins JM; Department of Cell and Developmental Biology, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA.
  • Van Eyk JE; Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Vidal M; Department of Genetics, Harvard University, Cambridge, Massachusetts, USA.
  • Vogel C; New York University Center for Genomics and Systems Biology, New York University, New York, New York, USA.
  • Walt DR; Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Wyss Institute at Harvard University, Boston, Massachusetts, USA.
  • Kelleher NL; Department of Chemistry, Northwestern University, Evanston, Illinois, USA. Electronic address: n-kelleher@northwestern.edu.
Mol Cell Proteomics ; 21(7): 100254, 2022 07.
Article en En | MEDLINE | ID: mdl-35654359
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteoma / Proteómica Límite: Humans Idioma: En Revista: Mol Cell Proteomics Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteoma / Proteómica Límite: Humans Idioma: En Revista: Mol Cell Proteomics Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2022 Tipo del documento: Article