Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers.
Soft Matter
; 18(25): 4737-4746, 2022 Jun 29.
Article
en En
| MEDLINE
| ID: mdl-35703313
ABSTRACT
It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that connects cell-cell interactions specified at the single cell level to large-scale nematic and hydrodynamic properties of the tissue. In particular, we present a minimal formulation that reproduces the well-known bend and splay hydrodynamic instabilities of the continuum nemato-hydrodynamic formulation of active matter, together with an analytical description of the instability threshold in terms of activity and elasticity of the cells. Furthermore, we provide a quantitative characterisation and comparison of flows and topological defects for extensile and contractile stress generation mechanisms, and demonstrate activity-induced heterogeneity and spontaneous formation of gaps within a confluent monolayer. Together, these results contribute to bridging the gap between cell-scale dynamics and tissue-scale collective cellular organisation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Comunicación Celular
/
Cristales Líquidos
Idioma:
En
Revista:
Soft Matter
Año:
2022
Tipo del documento:
Article
País de afiliación:
Dinamarca