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1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.
Lu, Yanran; Mann, Chelsea A; Nolan, Sheri; Collins, Jessica A; Parker, Elizabeth; Papa, Jonathan; Vibhute, Sandip; Jahanbakhsh, Seyedehameneh; Thwaites, Mary; Hufnagel, David; Hazbón, Manzour H; Moreno, Jane; Stedman, Timothy T; Wittum, Thomas; Wozniak, Daniel J; Osheroff, Neil; Yalowich, Jack C; Mitton-Fry, Mark J.
Afiliación
  • Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
  • Mann CA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
  • Nolan S; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
  • Collins JA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Parker E; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
  • Papa J; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
  • Vibhute S; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
  • Jahanbakhsh S; Micromyx, Kalamazoo, Michigan 49008, United States.
  • Thwaites M; Micromyx, Kalamazoo, Michigan 49008, United States.
  • Hufnagel D; Micromyx, Kalamazoo, Michigan 49008, United States.
  • Hazbón MH; ATCC, Manassas, Virginia 20110, United States.
  • Moreno J; ATCC, Manassas, Virginia 20110, United States.
  • Stedman TT; ATCC, Manassas, Virginia 20110, United States.
  • Wittum T; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
  • Wozniak DJ; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
  • Osheroff N; Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, United States.
  • Yalowich JC; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Mitton-Fry MJ; Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
ACS Med Chem Lett ; 13(6): 955-963, 2022 Jun 09.
Article en En | MEDLINE | ID: mdl-35707162
ABSTRACT
Antibacterial resistance continues its devastation of available therapies. Novel bacterial topoisomerase inhibitors (NBTIs) offer one solution to this critical issue. Two series of amine NBTIs bearing tricyclic DNA-binding moieties as well as amide NBTIs with a bicyclic DNA-binding moiety were synthesized and evaluated against methicillin-resistant Staphylococcus aureus (MRSA). Additionally, these compounds and a series of bicyclic amine analogues displayed high activity against susceptible and drug-resistant Neisseria gonorrhoeae, expanding the spectrum of these dioxane-linked NBTIs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos