[Clinical and epidemiological characteristics of the Philadelphia negative myeloproliferative neoplasms in Chile]. / Características clínicas y epidemiológicas de las neoplasias mieloproliferativas Philadelphia negativas en el sistema público de salud de Chile.
Rev Med Chil
; 149(12): 1687-1693, 2021 Dec.
Article
en Es
| MEDLINE
| ID: mdl-35735335
ABSTRACT
BACKGROUND:
Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).AIM:
To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile. MATERIAL ANDMETHODS:
Retrospective review of medical records of all patients referred as MPN from 2012 to 2017. Patients with (9;21) translocation were excluded.RESULTS:
Data of 462 cases with a median age of 69 years from 10 public hospitals was reviewed. ET was the most frequently Ph-MNP found. The incidence of Ph-MPN was 1.5 x 100.000 cases. The JAK2 V617F mutation study was performed in 96% of patients and only 30% had a bone marrow biopsy. Thrombotic events were observed in 29% of patients. Bleeding events were observed in 7%. Five-year overall survival was 87%.CONCLUSIONS:
ET is the most frequent Ph-MPN. The mean incidence was lower than reported in the literature, in part because of a sub diagnosis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Policitemia Vera
/
Mielofibrosis Primaria
/
Trombocitemia Esencial
/
Trastornos Mieloproliferativos
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Humans
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev Med Chil
Año:
2021
Tipo del documento:
Article
País de afiliación:
Chile