Diterpenoid Constituents of Psiadia punctulata and Evaluation of Their Antimicrobial Activity.
J Nat Prod
; 85(7): 1667-1680, 2022 07 22.
Article
en En
| MEDLINE
| ID: mdl-35748331
ABSTRACT
Sixteen diterpenes (1-16), along with 10 previously described compounds, including four flavonoids and six diterpenes, were isolated from the aerial parts of Psiadia punctulata growing in Saudi Arabia. The diterpene structures were elucidated using NMR spectroscopy and mass spectrometry data. Furthermore, a DFT/NMR procedure was used to suggest the relative configuration of several compounds. The labdane-derived skeletons, namely, ent-atisane, ent-beyerene, ent-trachylobane, and ent-kaurene, were identified. The extracts, fractions, and pure compounds were then tested against Staphylococcus aureus, Streptococcus mutans, Treponema denticola, and Lactobacillus plantarum. One diterpenoid, namely, psiadin, showed an additive effect with the antiseptic chlorhexidine, with a fractional inhibitory concentration index of less than 1. Additionally, psiadin showed a prospective inhibition activity for bacterial efflux pumps.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asteraceae
/
Diterpenos
/
Antiinfecciosos
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
J Nat Prod
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia