2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

Vasu, Dhananjayan; Li, Huiying; Hardy, Christine D; Poulos, Thomas L; Silverman, Richard B

Vasu, Dhananjayan; Li, Huiying; Hardy, Christine D; Poulos, Thomas L; Silverman, Richard B.

Afiliación

Vasu D; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, United States.
Li H; Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, CA 92697-3900, United States.
Hardy CD; Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, CA 92697-3900, United States.
Poulos TL; Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, CA 92697-3900, United States. Electronic address: poulos@uci.edu.
Silverman RB; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, United States; Department of Pharmacology, Feinberg School of Medicine, Northwestern Unive

Bioorg Med Chem ; 69: 116878, 2022 09 01.

Article en En | MEDLINE | ID: mdl-35772285

Asunto(s)

Aminopiridinas; Óxido Nítrico; Aminopiridinas/química; Aminopiridinas/farmacología; Animales; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Humanos; Óxido Nítrico Sintasa; Óxido Nítrico Sintasa de Tipo I/química; Óxido Nítrico Sintasa de Tipo I/metabolismo; Isoformas de Proteínas; Ratas

Palabras clave

2-Aminopyridines; Blood-brain barrier; Fluorine; Molecular rigidity; Neurodegeneration; Nitric oxide; Nitric oxide synthases; PAMPA-BBB penetration

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aminopiridinas / Óxido Nítrico Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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