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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial.
Menon, Bijoy K; Buck, Brian H; Singh, Nishita; Deschaintre, Yan; Almekhlafi, Mohammed A; Coutts, Shelagh B; Thirunavukkarasu, Sibi; Khosravani, Houman; Appireddy, Ramana; Moreau, Francois; Gubitz, Gord; Tkach, Aleksander; Catanese, Luciana; Dowlatshahi, Dar; Medvedev, George; Mandzia, Jennifer; Pikula, Aleksandra; Shankar, Jai; Williams, Heather; Field, Thalia S; Manosalva, Alejandro; Siddiqui, Muzaffar; Zafar, Atif; Imoukhuede, Oje; Hunter, Gary; Demchuk, Andrew M; Mishra, Sachin; Gioia, Laura C; Jalini, Shirin; Cayer, Caroline; Phillips, Stephen; Elamin, Elsadig; Shoamanesh, Ashkan; Subramaniam, Suresh; Kate, Mahesh; Jacquin, Gregory; Camden, Marie-Christine; Benali, Faysal; Alhabli, Ibrahim; Bala, Fouzi; Horn, MacKenzie; Stotts, Grant; Hill, Michael D; Gladstone, David J; Poppe, Alexandre; Sehgal, Arshia; Zhang, Qiao; Lethebe, Brendan Cord; Doram, Craig; Ademola, Ayoola.
Afiliación
  • Menon BK; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgar
  • Buck BH; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Singh N; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Deschaintre Y; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada; Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
  • Almekhlafi MA; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgar
  • Coutts SB; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgar
  • Thirunavukkarasu S; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Khosravani H; Department of Medicine (Division of Neurology), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Appireddy R; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada.
  • Moreau F; Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Gubitz G; Queen Elizabeth Health Sciences Centre, Halifax, NS, Canada.
  • Tkach A; Kelowna General Hospital, Kelowna, BC, Canada.
  • Catanese L; Hamilton Health Sciences Centre and McMaster University, Hamilton, ON, Canada.
  • Dowlatshahi D; Department of Medicine, University of Ottawa and the Ottawa Heart Research Institute, Ottawa, ON, Canada.
  • Medvedev G; University of British Columbia and the Fraser Health Authority, New Westminster, BC, Canada.
  • Mandzia J; London Health Sciences Centre and Western University, London, ON, Canada.
  • Pikula A; Toronto Western Hospital and the University of Toronto, Toronto, ON, Canada.
  • Shankar J; University of Manitoba, Winnipeg, MB, Canada.
  • Williams H; Queen Elizabeth Hospital, Charlottetown, PE, Canada.
  • Field TS; Vancouver Stroke Program and the Division of Neurology, University of British Columbia, Vancouver, BC, Canada.
  • Manosalva A; Medicine Hat Regional Hospital, Medicine Hat, AB, Canada.
  • Siddiqui M; Grey Nuns Community Hospital, Edmonton, AB, Canada.
  • Zafar A; St Michael's Hospital, Toronto, ON, Canada.
  • Imoukhuede O; Red Deer Regional Hospital, Red Deer, AB, Canada.
  • Hunter G; University of Saskatchewan, Saskatoon, SK, Canada.
  • Demchuk AM; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgar
  • Mishra S; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Gioia LC; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada; Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
  • Jalini S; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada.
  • Cayer C; Centre de recherche du CHUS, Centre intégré Universitaire de Santé et des Services Sociaux de l'Estrie, Sherbrooke, QC, Canada.
  • Phillips S; Queen Elizabeth Health Sciences Centre, Halifax, NS, Canada.
  • Elamin E; Kelowna General Hospital, Kelowna, BC, Canada.
  • Shoamanesh A; Hamilton Health Sciences Centre and McMaster University, Hamilton, ON, Canada.
  • Subramaniam S; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Kate M; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Jacquin G; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada; Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
  • Camden MC; Enfant-Jésus Hospital, Centre Hospitalier Universitaire de Québec, Laval University, Québec City, QC, Canada.
  • Benali F; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Alhabli I; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Bala F; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Horn M; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Stotts G; Department of Medicine, University of Ottawa and the Ottawa Heart Research Institute, Ottawa, ON, Canada.
  • Hill MD; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgar
  • Gladstone DJ; Department of Medicine (Division of Neurology), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Poppe A; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada; Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
  • Sehgal A; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Zhang Q; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Lethebe BC; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
  • Doram C; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Ademola A; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Cumming School of Medicine and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Lancet ; 400(10347): 161-169, 2022 07 16.
Article en En | MEDLINE | ID: mdl-35779553
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / Accidente Cerebrovascular / Accidente Cerebrovascular Isquémico Tipo de estudio: Clinical_trials / Etiology_studies / Guideline Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Lancet Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / Accidente Cerebrovascular / Accidente Cerebrovascular Isquémico Tipo de estudio: Clinical_trials / Etiology_studies / Guideline Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Lancet Año: 2022 Tipo del documento: Article