Discovery of the oncogenic MDM2, a direct binding target of berberine and a potential therapeutic, in multiple myeloma.

Li, Chuting; Su, Ru; Wang, Xiuyuan; Huang, Guiping; Liu, Yanjun; Yang, Juhua; Yin, Zhao; Gu, Chunming; Fei, Jia

Li, Chuting; Su, Ru; Wang, Xiuyuan; Huang, Guiping; Liu, Yanjun; Yang, Juhua; Yin, Zhao; Gu, Chunming; Fei, Jia.

Afiliación

Li C; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Su R; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Wang X; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Huang G; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Liu Y; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Yang J; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Yin Z; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China.
Gu C; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China. guchunming@stu2016.jnu.edu.cn.
Fei J; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China. tfeijia@jnu.edu.cn.

Funct Integr Genomics ; 22(5): 1031-1041, 2022 Oct.

Article en En | MEDLINE | ID: mdl-35794284

Asunto(s)

Berberina; Mieloma Múltiple; Animales; Apoptosis; Berberina/farmacología; Berberina/uso terapéutico; Bortezomib/metabolismo; Carcinogénesis; Línea Celular Tumoral; Humanos; Ratones; Simulación del Acoplamiento Molecular; Mieloma Múltiple/tratamiento farmacológico; Mieloma Múltiple/genética; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteínas Proto-Oncogénicas c-mdm2/genética; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; ARN Interferente Pequeño; Proteína p53 Supresora de Tumor/genética; Ubiquitina

Palabras clave

BBR; Degradation; MDM2; Target identification; Ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Berberina / Mieloma Múltiple Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Funct Integr Genomics Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2022 Tipo del documento: Article País de afiliación: China

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