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Left ventricular function and volumes from gated [13N]-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET/MR device.
Maurer, Alexander; Sustar, Aleksandra; Giannopoulos, Andreas A; Grünig, Hannes; Bakula, Adam; Patriki, Dimitri; von Felten, Elia; Messerli, Michael; Pazhenkottil, Aju P; Gebhard, Catherine; Kaufmann, Philipp A; Buechel, Ronny R; Fuchs, Tobias A.
Afiliación
  • Maurer A; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Sustar A; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Giannopoulos AA; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Grünig H; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Bakula A; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Patriki D; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • von Felten E; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Messerli M; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Pazhenkottil AP; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Gebhard C; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Kaufmann PA; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Buechel RR; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Fuchs TA; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. tobiasfuchs@gmx.ch.
J Nucl Cardiol ; 30(2): 616-625, 2023 04.
Article en En | MEDLINE | ID: mdl-35819716
ABSTRACT

BACKGROUND:

Positron emission tomography (PET) myocardial perfusion imaging (MPI) can be used to evaluate left ventricular (LV) volumes and function. We performed a head-to-head comparison of LV function and volumes obtained simultaneously using [13N]-ammonia-PET and cardiac magnetic resonance (CMR), with the latter serving as the reference standard. METHODS AND

RESULTS:

In this prospective study, 51 patients underwent [13N]-ammonia-PET MPI and CMR using a hybrid PET/MR device. Left ventricular end-systolic volumes (LVESV), end-diastolic volumes (LVEDV), stroke volumes (LVSV), ejection fractions (LVEF), and segmental wall motion were analyzed for both methods and were compared using correlational and Bland-Altman (BA) analysis; segmental wall motion was compared using ANOVA. The agreement between [13N]-ammonia-PET and CMR for LVEF was good, with minimal bias (- .6%) and narrow BA limits of agreement (- 7.9% to 6.8%), but [13N]-ammonia-PET systematically underestimated LV volumes, with high bias in LVESV (- 11.2 ml), LVEDV (- 28.9 ml), and LVSV (- 17.5 ml). Mean segmental wall motion in [13N]-ammonia-PET differed significantly among the corresponding normokinetic (6.6 ± 2 mm), hypokinetic (5.1 ± 2 mm), and akinetic (3.3 ± 2 mm) segments in CMR (P < .01).

CONCLUSION:

LVEF and LV wall motion can be accurately assessed using [13N]-ammonia-PET MPI, although LV volumes are significantly underestimated compared to CMR.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Disfunción Ventricular Izquierda Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Disfunción Ventricular Izquierda Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza