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Mapping SARS-CoV-2 antigenic relationships and serological responses.
Wilks, Samuel H; Mühlemann, Barbara; Shen, Xiaoying; Türeli, Sina; LeGresley, Eric B; Netzl, Antonia; Caniza, Miguela A; Chacaltana-Huarcaya, Jesus N; Corman, Victor M; Daniell, Xiaoju; Datto, Michael B; Dawood, Fatimah S; Denny, Thomas N; Drosten, Christian; Fouchier, Ron A M; Garcia, Patricia J; Halfmann, Peter J; Jassem, Agatha; Jeworowski, Lara M; Jones, Terry C; Kawaoka, Yoshihiro; Krammer, Florian; McDanal, Charlene; Pajon, Rolando; Simon, Viviana; Stockwell, Melissa S; Tang, Haili; van Bakel, Harm; Veguilla, Vic; Webby, Richard; Montefiori, David C; Smith, Derek J.
Afiliación
  • Wilks SH; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Mühlemann B; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Shen X; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Türeli S; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
  • LeGresley EB; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
  • Netzl A; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Caniza MA; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Chacaltana-Huarcaya JN; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Corman VM; Department of Global Pediatric Medicine, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Daniell X; Hospital Nacional Daniel A Carrión, Callao, Bellavista, Peru.
  • Datto MB; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Dawood FS; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Denny TN; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
  • Drosten C; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.
  • Fouchier RAM; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Garcia PJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
  • Halfmann PJ; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Jassem A; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Jeworowski LM; Erasmus Medical Center, Rotterdam, Netherlands.
  • Jones TC; School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Kawaoka Y; Influenza Research Institute, Department of Pathobiological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Krammer F; BC Centre for Disease Control, Vancouver, British Columbia, Canada.
  • McDanal C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Pajon R; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Simon V; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  • Stockwell MS; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
  • Tang H; Influenza Research Institute, Department of Pathobiological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • van Bakel H; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Veguilla V; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Webby R; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan.
  • Montefiori DC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Smith DJ; Department of Pathology, Cellular and Molecular Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
bioRxiv ; 2023 Jun 16.
Article en En | MEDLINE | ID: mdl-35860221
ABSTRACT
During the SARS-CoV-2 pandemic, multiple variants escaping pre-existing immunity emerged, causing concerns about continued protection. Here, we use antigenic cartography to analyze patterns of cross-reactivity among a panel of 21 variants and 15 groups of human sera obtained following primary infection with 10 different variants or after mRNA-1273 or mRNA-1273.351 vaccination. We find antigenic differences among pre-Omicron variants caused by substitutions at spike protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months post-2nd dose. We find changes in immunodominance of different spike regions depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine strain selection.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido