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Treatment of radiation-induced brain injury with bisdemethoxycurcumin.
Chang, Yun-Qian; Zhou, Gui-Juan; Wen, Hong-Mei; He, Duan-Qun; Xu, Chen-Lin; Chen, Ya-Rui; Li, Yi-Hui; Chen, Shuang-Xi; Xiao, Zi-Jian; Xie, Ming.
Afiliación
  • Chang YQ; Department of Neurology, The First Affiliated Hospital; Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Zhou GJ; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Wen HM; Department of Nursing, Youxian People's Hospital, Zhuzhou, Hunan Province, China.
  • He DQ; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province; Department of Neurology, Shenzhen Baoan People's Hospital (Group), The Second People's Hospital, Shenzhen, Guangdong Province, China.
  • Xu CL; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province; Department of Neurology, Xiangxi Autonomous Prefecture People's Hospital, Jishou, Hunan Province, China.
  • Chen YR; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Li YH; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Chen SX; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Xiao ZJ; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
  • Xie M; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Neural Regen Res ; 18(2): 416-421, 2023 Feb.
Article en En | MEDLINE | ID: mdl-35900439
ABSTRACT
Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 µL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2023 Tipo del documento: Article País de afiliación: China