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Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?
Kreir, Mohamed; Floren, Wim; Policarpo, Rafaela; De Bondt, An; Van den Wyngaert, Ilse; Teisman, Ard; Gallacher, David J; Lu, Hua Rong.
Afiliación
  • Kreir M; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: mkreir@its.jnj.com.
  • Floren W; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Policarpo R; Neuroscience Therapeutic Area, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Belgium.
  • De Bondt A; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Van den Wyngaert I; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Teisman A; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Gallacher DJ; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Lu HR; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
Eur J Pharmacol ; 931: 175189, 2022 Sep 15.
Article en En | MEDLINE | ID: mdl-35987255
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Pluripotentes Inducidas Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Pluripotentes Inducidas Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Article