Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H<sup>+</sup>/K<sup>+</sup>-ATPase Pump, Oxidative Stress and Inflammatory Pathways.

Razzaq, Sidra; Minhas, Amber Mahmood; Qazi, Neelum Gul; Nadeem, Humaira; Khan, Arif-Ullah; Ali, Fawad; Hassan, Syed Shams Ul; Bungau, Simona

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H⁺/K⁺-ATPase Pump, Oxidative Stress and Inflammatory Pathways.

Razzaq, Sidra; Minhas, Amber Mahmood; Qazi, Neelum Gul; Nadeem, Humaira; Khan, Arif-Ullah; Ali, Fawad; Hassan, Syed Shams Ul; Bungau, Simona.

Afiliación

Razzaq S; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Minhas AM; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Qazi NG; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Nadeem H; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Khan AU; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Ali F; Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000, Pakistan.
Hassan SSU; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Bungau S; Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Molecules ; 27(16)2022 Aug 09.

Article en En | MEDLINE | ID: mdl-36014311

Asunto(s)

Antiulcerosos; Helicobacter pylori; Úlcera Gástrica; Animales; Antiulcerosos/química; Antioxidantes/metabolismo; Etanol/metabolismo; Mucosa Gástrica; Glutatión/metabolismo; ATPasa Intercambiadora de Hidrógeno-Potásio/metabolismo; Isoxazoles/farmacología; Estrés Oxidativo; Extractos Vegetales/química; Proteómica; Ratas; Úlcera Gástrica/inducido químicamente; Úlcera Gástrica/tratamiento farmacológico; Úlcera Gástrica/prevención & control

Palabras clave

H+/K+-ATPase inhibition; anti-inflammatory; antioxidant; gastric ulcer; in-silico; isoxazole

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Úlcera Gástrica / Helicobacter pylori / Antiulcerosos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Pakistán

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