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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.
Jansen, Iris E; van der Lee, Sven J; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M; Wightman, Douglas P; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biessels, Geert Jan; Blennow, Kaj; Blesa, Rafael; Boada, Mercè; Boland, Anne; Buerger, Katharina; Carracedo, Ángel; Cervera-Carles, Laura; Chene, Geneviève; Claassen, Jurgen A H R; Debette, Stephanie; Deleuze, Jean-Francois; de Deyn, Peter Paul; Diehl-Schmid, Janine; Djurovic, Srdjan; Dols-Icardo, Oriol; Dufouil, Carole; Duron, Emmanuelle; Düzel, Emrah; Fladby, Tormod; Fortea, Juan; Frölich, Lutz; García-González, Pablo.
Afiliación
  • Jansen IE; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
  • van der Lee SJ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
  • Gomez-Fonseca D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
  • de Rojas I; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
  • Dalmasso MC; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Grenier-Boley B; Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Zettergren A; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Mishra A; NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
  • Ali M; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  • Andrade V; Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
  • Bellenguez C; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
  • Kleineidam L; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Küçükali F; Neurosciences and Complex Systems Unit (ENyS), CONICET, Hospital El Cruce, National University A. Jauretche (UNAJ), Florencio Varela, Argentina.
  • Sung YJ; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  • Tesí N; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
  • Vromen EM; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.
  • Wightman DP; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Alcolea D; NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
  • Alegret M; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  • Alvarez I; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Amouyel P; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
  • Athanasiu L; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  • Bahrami S; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Bailly H; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
  • Belbin O; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Bergh S; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
  • Bertram L; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Biessels GJ; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Blennow K; NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
  • Blesa R; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  • Boada M; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
  • Boland A; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Buerger K; Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Carracedo Á; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
  • Cervera-Carles L; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Chene G; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
  • Claassen JAHR; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
  • Debette S; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Deleuze JF; Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
  • de Deyn PP; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
  • Diehl-Schmid J; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
  • Djurovic S; Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, Terrassa, Spain.
  • Dols-Icardo O; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  • Dufouil C; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.
  • Duron E; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.
  • Düzel E; Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.
  • Fladby T; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Fortea J; The Research-Centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Brumunddal, Norway.
  • Frölich L; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
  • García-González P; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Acta Neuropathol ; 144(5): 821-842, 2022 11.
Article en En | MEDLINE | ID: mdl-36066633
ABSTRACT
Amyloid-beta 42 (Aß42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aß42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aß42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos