Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.
Am J Gastroenterol
; 117(11): 1877-1879, 2022 11 01.
Article
en En
| MEDLINE
| ID: mdl-36087100
ABSTRACT
INTRODUCTION:
Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia.METHODS:
This was a retrospective analysis of colonoscopy outcomes in patients with germline CDH1 pathogenic/likely pathogenic variants.RESULTS:
Eighty-five patients were included with a mean age of 46.9 years. Initial colonoscopy found adenomatous polyps in 30 patients (35.3%), including advanced adenomas in 9 (10.6%). No colorectal cancers were identified on index or subsequent colonoscopies (when available).DISCUSSION:
CDH1 carriers have colorectal neoplasia identified at similar rates as in the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Neoplasias Colorrectales
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos