The use of thiphenamil hydrochloride (Trocinate) to control wound contraction after radial keratotomy.
Ophthalmic Surg
; 18(6): 428-31, 1987 Jun.
Article
en En
| MEDLINE
| ID: mdl-3614824
ABSTRACT
We studied the efficacy of a topical smooth muscle antagonist, thiphenamil hydrochloride (Trocinate), in inhibiting wound contraction in ocular tissue. Fifteen New Zealand white rabbits underwent standard eight-incision radial keratotomy (RK), and eyes were randomly assigned to treatment or control groups. As demonstrated by slit lamp corneal photographs and by ocular histology, transient inhibition of wound contraction lasted approximately one week in all treatment eyes. We conclude that thiphenamil has a temporary, but specific, effect in controlling wound contraction after ocular surgery. Smooth muscle antagonists may be useful for managing cicatricial conditions of the eye.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Queratotomía Radial
/
Córnea
/
Ácidos Difenilacéticos
/
Músculo Liso
Límite:
Animals
Idioma:
En
Revista:
Ophthalmic Surg
Año:
1987
Tipo del documento:
Article