Your browser doesn't support javascript.
loading
Endocannabinoid signaling in microglia.
Marinelli, Sara; Marrone, Maria Cristina; Di Domenico, Marina; Marinelli, Silvia.
Afiliación
  • Marinelli S; CNR-National Research Council, Institute of Biochemistry and Cell Biology, Rome, Italy.
  • Marrone MC; EBRI-Fondazione Rita Levi Montalcini, Rome, Italy.
  • Di Domenico M; Ministry of University and Research, Mission Unity for Recovery and Resilience Plan, Rome, Italy.
  • Marinelli S; EBRI-Fondazione Rita Levi Montalcini, Rome, Italy.
Glia ; 71(1): 71-90, 2023 01.
Article en En | MEDLINE | ID: mdl-36222019
ABSTRACT
Microglia, the innate immune cells of the central nervous system (CNS), execute their sentinel, housekeeping and defense functions through a panoply of genes, receptors and released cytokines, chemokines and neurotrophic factors. Moreover, microglia functions are closely linked to the constant communication with other cell types, among them neurons. Depending on the signaling pathway and type of stimuli involved, the outcome of microglia operation can be neuroprotective or neurodegenerative. Accordingly, microglia are increasingly becoming considered cellular targets for therapeutic intervention. Among signals controlling microglia activity, the endocannabinoid (EC) system has been shown to exert a neuroprotective role in many neurological diseases. Like neurons, microglia express functional EC receptors and can produce and degrade ECs. Interestingly, boosting EC signaling leads to an anti-inflammatory and neuroprotective microglia phenotype. Nonetheless, little evidence is available on the microglia-mediated therapeutic effects of EC compounds. This review focuses on the EC signals acting on the CNS microglia in physiological and pathological conditions, namely on the CB1R, CB2R and TRPV1-mediated regulation of microglia properties. It also provides new evidence, which strengthens the understanding of mechanisms underlying the control of microglia functions by ECs. Given the broad expression of the EC system in glial and neuronal cells, the resulting picture is the need for in vivo studies in transgenic mouse models to dissect the contribution of EC microglia signaling in the neuroprotective effects of EC-derived compounds.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Fármacos Neuroprotectores Límite: Animals Idioma: En Revista: Glia Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Fármacos Neuroprotectores Límite: Animals Idioma: En Revista: Glia Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia