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Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins.
Kalshetti, Rupali G; Rajput, Raveena; Motiwala, Zenia; Srinivasa Reddy, D; Kulkarni, Kiran A; Ramana, Chepuri V.
Afiliación
  • Kalshetti RG; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
  • Rajput R; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
  • Motiwala Z; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
  • Srinivasa Reddy D; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
  • Kulkarni KA; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: ka.kulkarni@ncl.res.in.
  • Ramana CV; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: vr.chepuri@ncl.res.in.
Bioorg Med Chem Lett ; 77: 129022, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36241050
The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored with simple as well as conjugated olefins to synthesize post-functionalized GBT-440 analogues. The screening of these synthesized compounds for improving the oxygen binding efficiency of the hemoglobin isolated from the sickled red blood cells revealed that some of these compounds are as good as GBT-440.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzaldehídos / Alquenos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzaldehídos / Alquenos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: India