Electroreductive Ring-Opening Carboxylation of Cycloketone Oxime Esters with Carbon Dioxide.
J Org Chem
; 88(8): 5212-5219, 2023 Apr 21.
Article
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| MEDLINE
| ID: mdl-36273332
ABSTRACT
Electroreductive ring-opening carboxylation of cycloketone oxime esters with atmospheric carbon dioxide is reported. This reaction proceeded under simple constant current conditions in an undivided cell using glassy carbon as the cathode and magnesium as the sacrificial anode, providing substituted γ- and δ-cyanocarboxylic acids in moderate to good yields. Electrochemically generated cyanoalkyl radicals and cyanoalkyl anion are proposed as the key intermediates.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2023
Tipo del documento:
Article