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The Naked Mole-Rat as a Model for Healthy Aging.
Oka, Kaori; Yamakawa, Masanori; Kawamura, Yoshimi; Kutsukake, Nobuyuki; Miura, Kyoko.
Afiliación
  • Oka K; Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; email: okaori@kumamoto-u.ac.jp, kawamuray@kumamoto-u.ac.jp, miurak@kumamoto-u.ac.jp.
  • Yamakawa M; Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies), Kanagawa, Japan; email: yamakawa_masanori@soken.ac.jp, kutsu@soken.ac.jp.
  • Kawamura Y; Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; email: okaori@kumamoto-u.ac.jp, kawamuray@kumamoto-u.ac.jp, miurak@kumamoto-u.ac.jp.
  • Kutsukake N; Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies), Kanagawa, Japan; email: yamakawa_masanori@soken.ac.jp, kutsu@soken.ac.jp.
  • Miura K; Research Center for Integrative Evolutionary Science, Sokendai (The Graduate University for Advanced Studies), Kanagawa, Japan.
Annu Rev Anim Biosci ; 11: 207-226, 2023 02 15.
Article en En | MEDLINE | ID: mdl-36318672
ABSTRACT
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and resistance to age-related functional decline/diseases. Specifically, they do not display increased mortality with age, maintain several physiological functions until nearly the end of their lifetime, and rarely develop cancer and Alzheimer's disease. NMRs live in a hypoxic environment in underground colonies in East Africa and are highly tolerant of hypoxia. These unique characteristics of NMRs have attracted considerable interest from zoological and biomedical researchers. This review summarizes previous studies of the ecology, hypoxia tolerance, longevity/delayed aging, and cancer resistance of NMRs and discusses possible mechanisms contributing to their healthy aging. In addition, we discuss current issues and future perspectives to fully elucidate the mechanisms underlying delayed aging and resistance to age-related diseases in NMRs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento Saludable Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Annu Rev Anim Biosci Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento Saludable Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Annu Rev Anim Biosci Año: 2023 Tipo del documento: Article