Unified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones.
Chem Sci
; 13(36): 10743-10751, 2022 Sep 21.
Article
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| MEDLINE
| ID: mdl-36320688
ABSTRACT
A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a Friedel-Crafts type alkylation to afford the corresponding multiply arylated alkanes. A variety of diarylketones can be converted to multiply arylated alkanes such as diarylmethanes, tetraarylethanes, and triarylmethanes by reduction, dimerization, and arylation in one pot. Furthermore, a one-pot conversion from arylcarboxylic acids to diarylmethanes and tetraarylethanes, and a synthesis of tetraarylmethane and triphenylethane using sequential coupling reactions are also presented.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2022
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Article