Your browser doesn't support javascript.
loading
Enhanced and specific epoxidation activity of P450 BM3 mutants for the production of high value terpene derivatives.
Correddu, Danilo; Helmy Aly, Sabrina; Di Nardo, Giovanna; Catucci, Gianluca; Prandi, Cristina; Blangetti, Marco; Bellomo, Chiara; Bonometti, Elisabetta; Viscardi, Guido; Gilardi, Gianfranco.
Afiliación
  • Correddu D; Department of Life Sciences and Systems Biology, University of Torino Via Accademia Albertina 13 10123 Torino Italy gianfranco.gilardi@unito.it.
  • Helmy Aly S; Department of Life Sciences and Systems Biology, University of Torino Via Accademia Albertina 13 10123 Torino Italy gianfranco.gilardi@unito.it.
  • Di Nardo G; Department of Life Sciences and Systems Biology, University of Torino Via Accademia Albertina 13 10123 Torino Italy gianfranco.gilardi@unito.it.
  • Catucci G; Department of Life Sciences and Systems Biology, University of Torino Via Accademia Albertina 13 10123 Torino Italy gianfranco.gilardi@unito.it.
  • Prandi C; Department of Chemistry, University of Torino Via P. Giuria 7 10125 Torino Italy.
  • Blangetti M; Department of Chemistry, University of Torino Via P. Giuria 7 10125 Torino Italy.
  • Bellomo C; Department of Chemistry, University of Torino Via P. Giuria 7 10125 Torino Italy.
  • Bonometti E; Department of Chemistry, University of Torino Via P. Giuria 7 10125 Torino Italy.
  • Viscardi G; Department of Chemistry, University of Torino Via P. Giuria 7 10125 Torino Italy.
  • Gilardi G; Department of Life Sciences and Systems Biology, University of Torino Via Accademia Albertina 13 10123 Torino Italy gianfranco.gilardi@unito.it.
RSC Adv ; 12(52): 33964-33969, 2022 Nov 22.
Article en En | MEDLINE | ID: mdl-36505709
ABSTRACT
Terpenes are natural molecules of valuable interest for different industrial applications. Cytochromes P450 enzymes can functionalize terpenoids to form high value oxidized derivatives in a green and sustainable manner, representing a valid alternative to chemical catalysis. In this work, an enhanced and specific epoxidation activity of cytochrome P450 BM3 mutants was found for the terpenes geraniol and linalool. This is the first report showing the epoxidation of linalool by P450 BM3 and its mutant A2 (Asp251Gly/Gln307His) with the formation of valuable oxide derivatives, highlighting the relevance of this enzymes for industrial applications.
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article