Tumor Targeting and pH-Sensitive Inclusion Complex Based on HP-ß-CD as a Potential Carrier for Paclitaxel: Fabrication, Molecular Docking, and Characterization.
Biomacromolecules
; 24(1): 178-189, 2023 01 09.
Article
en En
| MEDLINE
| ID: mdl-36538015
ABSTRACT
In this study, a tumor-targeting and pH-sensitive inclusion complex based on the host-guest recognition between the chitosan and folic acid grafted HP-ß-CD (FA-CS-CD) and stearic acid modified 2-benzimidazolemethanol (BM-SA) was designed and fabricated for the controlled delivery of paclitaxel (PTX). Through the combination of computational simulations and experiments, the interaction between FA-CS-CD, BM-SA, and PTX was investigated, and the optimized preparation method was obtained. For the optimized PTX-loaded FA-CS-CD/BM-SA inclusion complex, the particle size and zeta potential were 146 nm and +15.4 mV, respectively. In vitro drug release study revealed the pH-triggered drug release behavior of the inclusion complex. Both in vitro and in vivo evaluations demonstrated that the PTX-loaded FA-CS-CD/BM-SA inclusion complex exhibited enhanced antitumor efficiency and minimized systemic toxicity. This system might be a promising carrier for PTX.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quitosano
/
Neoplasias
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biomacromolecules
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2023
Tipo del documento:
Article
País de afiliación:
China