Keratin intrinsic fluorescence as a mechanism for non-invasive monitoring of its glycation.
Methods Appl Fluoresc
; 11(1)2022 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-36541527
ABSTRACT
We have studied the evolution of keratin intrinsic fluorescence as an indicator of its glycation. Steady-state and time-resolved fluorescence of free keratin and keratin-glucose samples were detected in PBS solutionsin vitro. The changes in the fluorescence response demonstrate that the effect of glucose is manifest in the accelerated formation of fluorescent cross-links with an emission peak at 460 nm and formation of new cross-links with emission peaks at 525 nm and 575 nm. The fluorescence kinetics of these structures is studied and their potential application for the detection of long-term complications of diabetes discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reacción de Maillard
/
Queratinas
Idioma:
En
Revista:
Methods Appl Fluoresc
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido