Simultaneous determination of regional cerebral blood flow, glucose metabolism, and pH in acute experimental allergic encephalomyelitis.
J Cereb Blood Flow Metab
; 7(5): 578-84, 1987 Oct.
Article
en En
| MEDLINE
| ID: mdl-3654798
ABSTRACT
Regional cerebral blood flow (rCBF), regional cerebral glucose metabolic rate (rCMR), and regional pH (r-pH) were measured simultaneously in fulminant acute experimental allergic encephalomyelitis (EAE) by the use of triple-label autoradiography. No changes were found in the absence of lesions (lymphocytic accumulations). In the lesions, rCBF was 79% increased and rCRM was 13% increased, whereas r-pH was unaltered compared to normal values. The reported changes result in a CBF/CMR ratio of almost 3 in the lesions compared to the normal value of 1.5. The changes may be interpreted as primary disturbances in glucose metabolism, resulting in a secondary increase in CBF. This theory is supported by quoted observations on abnormal morphology and abnormal enzyme content in brain mitochondria in EAE.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Circulación Cerebrovascular
/
Encefalomielitis
/
Glucosa
/
Hidrógeno
Límite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Año:
1987
Tipo del documento:
Article
País de afiliación:
Dinamarca