In Vitro Hypoglycemic Diterpenoids from the Roots of Croton yunnanensis.
J Nat Prod
; 86(1): 199-208, 2023 01 27.
Article
en En
| MEDLINE
| ID: mdl-36635870
ABSTRACT
Fifteen compounds including nine new diterpenes were isolated from the roots of Croton yunnanensis. By HRESIMS, NMR, ECD data, and X-ray diffraction analysis, the new compounds were characterized as eight neo-clerodane diterpenes (compounds 1-8) and one 15,16-dinor-ent-pimarane diterpene (9). All diterpenes were assayed for their hypoglycemic activities. Compounds 1-4, 6, 7, and 10 promoted glucose uptake activity in insulin-resistant 3T3-L1 adipocytes. Compounds 1 and 6 showed insulin sensitizing activity, potentiating conspicuously their glucose uptake activity at a concentration of 20 µM when treated synergistically with low-concentration insulin at 1 nM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Croton
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Diterpenos de Tipo Clerodano
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Diterpenos
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Insulinas
Idioma:
En
Revista:
J Nat Prod
Año:
2023
Tipo del documento:
Article