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Strategies for refinement of occupational inhalation exposure evaluation in the EPA TSCA risk evaluation process.
Lynch, Heather N; Allen, Laura H; Hamaji, Claire M; Maier, Andrew.
Afiliación
  • Lynch HN; 205740Stantec (ChemRisk), Boston, MA, USA.
  • Allen LH; Stantec (ChemRisk), Pittsburgh, PA, USA.
  • Hamaji CM; Stantec (ChemRisk), San Francisco, CA, USA.
  • Maier A; Stantec (ChemRisk), Blue Ash, OH, USA.
Toxicol Ind Health ; 39(3): 169-182, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36656073
The focus on occupational exposures in the first published risk evaluations of existing chemicals by the Environmental Protection Agency (EPA) under the amended Toxic Substances Control Act (TSCA) puts a welcome spotlight on protecting the health of workers in the United States. Because new, fit-for-purpose occupational exposure assessment methodologies were developed by EPA, the objective of this analysis was to evaluate these methodologies in light of other existing occupational risk assessment frameworks. We focused our analysis on three chlorinated chemicals (methylene chloride, carbon tetrachloride, perchloroethylene). The EPA's methods were evaluated relative to peer-reviewed and professional organizations' guidelines for conducting site- and facility-based exposure assessment. Analyses of several key phases in the EPA approach were conducted to evaluate the effect of alternative approaches on exposure estimates. The revised exposure estimates using these alternative approaches yielded substantially different exposure estimates from those in the TSCA risk evaluations for these chemicals. The results also demonstrated the importance of utilizing a tiered approach to exposure estimation that includes collecting qualitative data, defining similar exposure groups, and integrating well-parameterized models with empirical data. These approaches aid in preventing mischaracterization of exposures and generating exposure estimates representative of current industrial practices. Collaboration among industry, EPA, and other government agencies to develop a harmonized approach to exposure assessment would improve the methodological rigor of, and increase stakeholder confidence in, the results of TSCA risk evaluations.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Exposición Profesional / Exposición por Inhalación Tipo de estudio: Etiology_studies / Guideline / Qualitative_research / Risk_factors_studies Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Exposición Profesional / Exposición por Inhalación Tipo de estudio: Etiology_studies / Guideline / Qualitative_research / Risk_factors_studies Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos