What percentage of patients with cancer develop hiccups with oxaliplatin- or cisplatin-based chemotherapy? a compilation of patient-reported outcomes.
PLoS One
; 18(1): e0280947, 2023.
Article
en En
| MEDLINE
| ID: mdl-36706101
ABSTRACT
BACKGROUND:
Chemotherapy-induced hiccups are understudied but can cause sleep deprivation, fatigue, pain in the chest and abdomen, poor oral intake, aspiration, and even death. As a critical next step toward investigating better palliative methods, this study reported patient-reported incidence of hiccups after oxaliplatin- or cisplatin-based chemotherapy.METHODS:
The current study relied on 2 previous studies that sought to acquire consecutive direct patient report of hiccups among patients who had recently received chemotherapy with cisplatin or oxaliplatin. These patient-reported data in conjunction with information from the medical record are the focus of this report.RESULTS:
Of 541 patients, 337 were successful contacted by phone; and 95 (28%; 95% CI 23%, 33%) of these contacted patients reported hiccups. In univariable analyses, male gender (odds ratio (OR) 2.17 (95% confidence ratio (95% CI) 1.30, 3.62); p = 0.002), increased height (OR 1.03 (95% CI 1.00, 1.06); p = 0.02), and concomitant aprepitant/fosaprepitant (OR 2.23 (95% CI 1.31, 3.78); p = 0.002) were associated with hiccups. In multivariable analyses, these statistically significant associations persisted except for height.CONCLUSIONS:
These patient-reported data demonstrate that oxaliplatin- or cisplatin-induced hiccups occur in a notable proportion of patients with cancer. Male gender and concomitant aprepitant/fosaprepitant appear to increase risk.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipo
/
Antieméticos
/
Neoplasias
Límite:
Humans
/
Male
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos