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Ruxolitinib Alleviates Inflammation, Apoptosis, and Intestinal Barrier Leakage in Ulcerative Colitis via STAT3.
Li, Chunxiao; Xu, Yu; Gao, Tengjiao; Zhang, Shunyao; Lin, Zhe; Gu, Shaobo; Fang, Yi; Yuan, Xin; Yu, Siyi; Jiang, Qi; Lou, Zhongze; Zhang, Xiuming; Zhang, Jie; Wu, Qiaoyan; Gu, Mengli; Ding, Xiaoyun; Sun, Jing; Chen, Yi.
Afiliación
  • Li C; Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Xu Y; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Gao T; Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Zhang S; Department of Gastroenterology, Ningbo Yinzhou No.2 Hospital, Ningbo, China.
  • Lin Z; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Gu S; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Fang Y; Department of Orthopedics, Hua Mei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China.
  • Yuan X; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Yu S; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Jiang Q; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Lou Z; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Zhang X; Central Laboratory of the Medical Research Center, Ningbo First Hospital, Ningbo, China.
  • Zhang J; Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, China.
  • Wu Q; Department of Pathology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Gu M; Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Ding X; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Sun J; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
  • Chen Y; Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
Inflamm Bowel Dis ; 29(8): 1191-1201, 2023 08 01.
Article en En | MEDLINE | ID: mdl-36721335
We studied the effect and mechanism of ruxolitinib on ulcerative colitis. We discovered that ruxolitinib administration significantly alleviated murine colitis by relieving disease activity and prolonged survival through intestinal epithelial cell nuclear factor kappa B­induced inflammation, reduced apoptosis, and ameliorated epithelial barrier leakage via STAT3.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China