Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.

Cil, Onur; Anderson, Marc O; de Souza Goncalves, Livia; Tan, Joseph-Anthony; Haggie, Peter M; Verkman, Alan S

Cil, Onur; Anderson, Marc O; de Souza Goncalves, Livia; Tan, Joseph-Anthony; Haggie, Peter M; Verkman, Alan S.

Afiliación

Cil O; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. Electronic address: onur.cil@ucsf.edu.
Anderson MO; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, USA.
de Souza Goncalves L; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Tan JA; Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA, USA.
Haggie PM; Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA, USA.
Verkman AS; Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA, USA.

Eur J Med Chem ; 249: 115149, 2023 Mar 05.

Article en En | MEDLINE | ID: mdl-36724632

Asunto(s)

Antiportadores; Estreñimiento; Ratones; Animales; Antiportadores/química; Antiportadores/metabolismo; Antiportadores/farmacología; Simulación del Acoplamiento Molecular; Transporte Biológico; Aniones; Cloruros/metabolismo; Transportadores de Sulfato/metabolismo

Palabras clave

Constipation; Down-regulated in adenoma; Kidney stones; Non-absorbable drugs; SLC26

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antiportadores / Estreñimiento Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article

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