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Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases.
Zhang, Rong; Zhang, Lan; Li, Peishan; Pang, Kaiyun; Liu, Huixia; Tian, Li.
Afiliación
  • Zhang R; College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China, cheung0213@hotmail.com.
  • Zhang L; College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Li P; Department of Otorhinolaryngology, The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Pang K; Department of Otorhinolaryngology, The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Liu H; College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Tian L; Department of Otorhinolaryngology, The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Int Arch Allergy Immunol ; 184(5): 481-501, 2023.
Article en En | MEDLINE | ID: mdl-36724763
As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations. Risk factors from both internal and external environments can disrupt them. External risk factors contain allergens containing proteases, bacteria, virus, particulate matter, diesel exhaust particles, and cigarette smoke. In the meantime, inflammatory cytokines also increase the load on the barrier. Taking into account the role of the epithelial barrier in the nasal mucosa, some studies focus on the treatment of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) by restoring the epithelial barrier, and some progress has been made. Among the therapeutic approaches, histone deacetylase (HDAC) inhibitor and steroid corticosteroids are considered two of the more studied categories, and their roles in repairing barriers have been demonstrated in AR and CRS. The underlying mechanism of HDAC inhibitor may be related to the transcription factor p63. And the protection of corticosteroids may be associated with the allergic disease susceptibility gene, protocadherin-1. Notably, manipulation of the microbiological barrier also has a positive effect on AR and CRS. Lactococcus and probiotics are two categories that are worth being explored continuously. We here review and discuss the compositions and risk factors of the nasal epithelial barrier. Furthermore, some novel and promising approaches to restore the defective barrier in nasal allergic diseases were mentioned.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinusitis / Rinitis Alérgica Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinusitis / Rinitis Alérgica Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article