Cyclic AMP (cAMP)-dependent proteolysis of GATA6 by proteasome: Zinc-finger domain of GATA6 has signals for nuclear export and proteolysis, both of which are responsive to cAMP.

Yamamoto, Tomohisa; Tsuge, Takeshi; Araki, Makoto; Maeda, Masatomo

Yamamoto, Tomohisa; Tsuge, Takeshi; Araki, Makoto; Maeda, Masatomo.

Afiliación

Yamamoto T; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Tsuge T; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Araki M; Meiji Pharmaceutical University, Tokyo, Japan.
Maeda M; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

Drug Discov Ther ; 17(1): 1-9, 2023 Mar 11.

Article en En | MEDLINE | ID: mdl-36740253

Asunto(s)

AMP Cíclico; Complejo de la Endopetidasa Proteasomal; Cricetinae; Animales; Complejo de la Endopetidasa Proteasomal/metabolismo; AMP Cíclico/metabolismo; Transporte Activo de Núcleo Celular; Bucladesina/metabolismo; Células CHO; Proteolisis; Cricetulus; Citoplasma/metabolismo; Núcleo Celular/metabolismo; Zinc/metabolismo

Palabras clave

Cyclic AMP-dependent protein kinase; GATA DNA-binding protein; cJun N-terminal kinase; nuclear-cytoplasmic shuttling; regulated protein degradation; stable transfection

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: AMP Cíclico / Complejo de la Endopetidasa Proteasomal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Discov Ther Año: 2023 Tipo del documento: Article País de afiliación: Japón

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