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Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus.
Ellison, Tim S; Cappa, Stefano F; Garrett, Dawne; Georges, Jean; Iwatsubo, Takeshi; Kramer, Joel H; Lehmann, Maryna; Lyketsos, Constantine; Maier, Andrea B; Merrilees, Jennifer; Morris, John C; Naismith, Sharon L; Nobili, Flavio; Pahor, Marco; Pond, Dimity; Robinson, Louise; Soysal, Pinar; Vandenbulcke, Mathieu; Weber, Christopher J; Visser, Pieter Jelle; Weiner, Michael; Frisoni, Giovanni B.
Afiliación
  • Ellison TS; PharmaGenesis London, London, UK.
  • Cappa SF; Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
  • Garrett D; Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy.
  • Georges J; Royal College of Nursing, London, UK.
  • Iwatsubo T; Alzheimer Europe, Luxembourg, Luxembourg.
  • Kramer JH; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan.
  • Lehmann M; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Lyketsos C; Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
  • Maier AB; World Dementia Council, George, South Africa.
  • Merrilees J; Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University and Medicine, Baltimore, USA.
  • Morris JC; Department of Medicine and Aged Care, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
  • Naismith SL; Faculty of Behavioural and Movement Sciences, Department of Human Movement Sciences, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, Netherlands.
  • Nobili F; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Pahor M; Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
  • Pond D; Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
  • Robinson L; Department of Neurology, Washington University, St. Louis, Missouri, USA.
  • Soysal P; School of Psychology, The University of Sydney, Sydney, New South Wales, Australia.
  • Vandenbulcke M; UO Clinica Neurologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genova, Italy.
  • Weber CJ; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Child and Mother Health, University of Genoa, Genova, Italy.
  • Visser PJ; Department of Aging and Geriatric Research, Institute on Aging, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Weiner M; Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
  • Frisoni GB; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Alzheimers Dement ; 19(6): 2707-2729, 2023 06.
Article en En | MEDLINE | ID: mdl-36749854
ABSTRACT

INTRODUCTION:

We aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.

METHODS:

A consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.

RESULTS:

Consensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.

DISCUSSION:

This work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido