Hypothetical interventions on risk factors for depression among middle-aged and older community-dwellers in China: An application of the parametric g-formula in a longitudinal study.
J Affect Disord
; 327: 355-361, 2023 04 14.
Article
en En
| MEDLINE
| ID: mdl-36754095
ABSTRACT
BACKGROUND:
Sleep disturbances, frailty, and body pain are widespread in middle-aged and older adults with depression, and have been identified as depression risk factors. However, there is a scarcity of research on the benefits of sleep improvement, frailty amelioration, and pain management on incident depression.METHODS:
A total of 8895 respondents aged above 45 years were derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2018. The parametric g-formula was used to estimate the 7-year risks of depression under independent hypothetical interventions on nighttime sleep duration (NSD), daytime napping duration (DND), perceived sleep quality (PSQ), frailty, and pain, as well as their various combinations.RESULTS:
The observed depression risk was 41.77 %. The independent intervention on frailty was the most effective in lowering incident depression, with a risk ratio (RR) of 0.61 (95 % CI 0.57-0.64), followed by PSQ (RR 0.75, 95 % CI 0.73-0.78), pain (RR 0.90, 95 % CI 0.87-0.91), and NSD (RR 0.96, 95 % CI 0.93-0.98). In subgroup analysis, intervention on NSD was more effective in men, PSQ was more effective in middle-aged individuals, and frailty and pain were more effective in older persons. The combined intervention of NSD, PSQ, frailty, and pain lowered the risk the greatest (RR 0.35, 95 % CI 0.32-0.37).LIMITATIONS:
Generalizing our results to other populations should be possible if they have the same distribution of effect modifiers and interference patterns because of the calculation principle of the parametric g-formula.CONCLUSIONS:
Interventions for sleep disturbances, frailty, and body pain can minimize the risk of depression.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragilidad
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
/
Humans
/
Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Affect Disord
Año:
2023
Tipo del documento:
Article
País de afiliación:
China