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Fraction of plasma exomeres and low-density lipoprotein cholesterol as a predictor of fatal outcome of COVID-19.
Usenko, Tatiana; Miroshnikova, Valentina; Bezrukova, Anastasia; Basharova, Katerina; Landa, Sergey; Korobova, Zoia; Liubimova, Natalia; Vlasov, Ivan; Nikolaev, Mikhael; Izyumchenko, Artem; Gavrilova, Elena; Shlyk, Irina; Chernitskaya, Elena; Kovalchuk, Yurii; Slominsky, Petr; Totolian, Areg; Polushin, Yurii; Pchelina, Sofya.
Afiliación
  • Usenko T; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Miroshnikova V; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Bezrukova A; Kurchatov Genome Center-PNPI, Saint-Petersburg, Russia.
  • Basharova K; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Landa S; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Korobova Z; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Liubimova N; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Vlasov I; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Nikolaev M; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Izyumchenko A; Saint Petersburg Pasteur Institute, Saint-Petersburg, Russia.
  • Gavrilova E; Saint Petersburg Pasteur Institute, Saint-Petersburg, Russia.
  • Shlyk I; Institute of Molecular Genetics, National Research Center "Kurchatov Institute", Moscow, Russia.
  • Chernitskaya E; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Kovalchuk Y; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Slominsky P; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute¼, Gatchina, Russia.
  • Totolian A; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Polushin Y; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
  • Pchelina S; Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
PLoS One ; 18(2): e0278083, 2023.
Article en En | MEDLINE | ID: mdl-36758022
Transcriptomic analysis conducted by us previously revealed upregulation of genes involved in low-density lipoprotein particle receptor (LDLR) activity pathway in lethal COVID-19 caused by SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). Last data suggested the possible role of extracellular vesicles in COVID-19 pathogenesis. The aim of the present study was to retrospectively evaluate parameters of cholesterol metabolism and newly identified EVs, exomeres, as possible predictors of fatal outcome of COVID-19 patients infected by the Alpha and the Delta variants of SARS-CoV-2 virus. Blood from 67 patients with severe COVID-19 were collected at the time of admission to the intensive care unit (ICU) and 7 days after admission to the ICU. After 30 days patients were divided into two subgroups according to outcome-34 non-survivors and 33 survivors. This study demonstrated that plasma low- and high-density lipoprotein cholesterol levels (LDL-C and HDL-C) were decreased in non-survivors compared to controls at the time of admission to the ICU. The conjoint fraction of exomeres and LDL particles measured by dynamic light scattering (DLS) was decreased in non-survivors infected by the Alpha and the Delta variants compared to survivors at the time of admission to the ICU. We first showed that reduction of exomeres fraction may be critical in fatal outcome of COVID-19.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Rusia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Rusia