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Phenylketonuria and complex spatial visualization: an analysis of information processing.
Brunner, R L; Berch, D B; Berry, H.
Afiliación
  • Brunner RL; Division of Basic Science Research, Children's Hospital Medical Center, Cincinnati, Ohio 45267.
Dev Med Child Neurol ; 29(4): 460-8, 1987 Aug.
Article en En | MEDLINE | ID: mdl-3678625
Recent neuropsychological studies have suggested that patients with early-treated phenylketonuria (PKU) and normal intelligence have a specific deficiency in solving complex spatial problems. In the present study a task involving the assembly of various shapes was used to compare the performance of 16 PKU patients and 11 sibling controls. Error rates generally were higher and response times slower among the PKU patients, but greater complexity did not produce differential changes in accuracy or speed in the PKU group compared to the controls. Correlations between task performance and IQ measures were significant for the PKU patients, but when IQ was controlled for the group differences vanished. The results suggest that choice of problem-solving strategy, attention span and accuracy of mental representation may be affected in PKU patients, despite efforts to maintain well-controlled phenylalanine concentrations in the blood.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenilcetonurias / Percepción de Forma Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Dev Med Child Neurol Año: 1987 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenilcetonurias / Percepción de Forma Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Dev Med Child Neurol Año: 1987 Tipo del documento: Article