Risk of type 2 diabetes mellitus between adolescents with antidepressant-resistant and antidepressant-responsive depression: A cohort study of 15,651 adolescents.
J Affect Disord
; 328: 210-214, 2023 05 01.
Article
en En
| MEDLINE
| ID: mdl-36806660
ABSTRACT
BACKGROUND:
Whether response to antidepressants is related to the risk of developing type 2 diabetes mellitus (T2DM) in adolescents with depression remains unknown.METHODS:
This study used the Taiwan National Health Insurance Research Database to enroll 1739 adolescents with antidepressant-resistant depression, 6956 with antidepressant-responsive depression, and 6956 controls between 2001 and 2010, with an end-of-2011 follow-up. Physician-diagnosed T2DM was identified at follow-up. T2DM-related risk factors, namely hypertension, dyslipidemia, and obesity, were assessed and controlled for as confounding factors.RESULTS:
Adolescents with antidepressant-resistant depression (hazard ratio [HR], 95 % confidence interval [CI] 4.62, 2.75-7.75) and those with antidepressant-responsive depression (HR, 95 % CI 3.06, 1.98-4.72) had a higher risk of developing T2DM at follow-up than did the control group. Those with antidepressant-resistant depression were more likely to receive a diagnosis of T2DM (HR, 95 % CI 1.51, 1.04-2.19) later in life than were those with antidepressant-responsive depression.DISCUSSION:
Clinicians should closely monitor factors related to T2DM, such as fasting blood sugar, in high-risk populations, especially in adolescents with antidepressant-resistant depression.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Humans
Idioma:
En
Revista:
J Affect Disord
Año:
2023
Tipo del documento:
Article
País de afiliación:
Taiwán