Usefulness of a humanized tricellular static transwell blood-brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system.

Nakayama-Kitamura, Kimiko; Shigemoto-Mogami, Yukari; Toyoda, Hiroko; Mihara, Ikue; Moriguchi, Hiroyuki; Naraoka, Hitoshi; Furihata, Tomomi; Ishida, Seiichi; Sato, Kaoru

Nakayama-Kitamura, Kimiko; Shigemoto-Mogami, Yukari; Toyoda, Hiroko; Mihara, Ikue; Moriguchi, Hiroyuki; Naraoka, Hitoshi; Furihata, Tomomi; Ishida, Seiichi; Sato, Kaoru.

Afiliación

Nakayama-Kitamura K; Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Science, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Shigemoto-Mogami Y; Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Science, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Toyoda H; Stem Cell Evaluation Technology Research Association, Grande Building 8F, 2-26-9 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan.
Mihara I; Stem Cell Evaluation Technology Research Association, Grande Building 8F, 2-26-9 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan.
Moriguchi H; Stem Cell Evaluation Technology Research Association, Grande Building 8F, 2-26-9 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan.
Naraoka H; Stem Cell Evaluation Technology Research Association, Grande Building 8F, 2-26-9 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan.
Furihata T; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 Japan.
Ishida S; Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Science, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki City, Kanagawa, Japan.
Sato K; Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto City, Kumamoto, Japan.

Regen Ther ; 22: 192-202, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36891355

Palabras clave

BBB, blood-brain barrier; BCRP; BCRP, Breast cancer resistance protein; Bloodâbrain barrier (BBB); CNS, central nervous system; Glut1, Glucose transporter 1; HASTR, Human astrocytes; HBMEC, Human brain microvascular endothelial cells; HBPC, Human brain pericyte; LC-MS/MS, Liquid chromatography with tandem mass spectrometry; LY, Lucifer yellow; MPS, Microphysiological system; Microphysiological system (MPS); P-gp; P-gp, P-glycoprotein; TEER, Trans-endothelial electrical resistance; TfR, Transferrin receptor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Regen Ther Año: 2023 Tipo del documento: Article País de afiliación: Japón

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