Start of life controlled by poly(A) tail-mediated remodeling.

Zhang, Chunxia; Zhang, Yi

Zhang, Chunxia; Zhang, Yi.

Afiliación

Zhang C; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. Electronic address: cxzhang@genetics.ac.cn.
Zhang Y; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, MA, USA; Harvard Stem Cell Institute, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address: yzhang@genetics.med.harvard.edu.

Trends Genet ; 39(5): 340-341, 2023 05.

Article en En | MEDLINE | ID: mdl-36907722

ABSTRACT

ABSTRACT

Understanding a remarkable event at the start of life, the oocyte-to-embryo transition (OET), has remained elusive, especially in humans. Using newly developed techniques, Liu et al. showed that human maternal mRNAs undergo global poly(A) tail-mediated remodeling during OET, identified the enzymes involved, and demonstrated the essentiality of remodeling for embryo cleavage.

Asunto(s)

Oocitos; ARN Mensajero Almacenado; Humanos; ARN Mensajero

Palabras clave

PAIso-seq; human; oocyte-to-embryo transition (OET); poly(A) tail; post-transcriptional regulation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oocitos / ARN Mensajero Almacenado Límite: Humans Idioma: En Revista: Trends Genet Asunto de la revista: GENETICA Año: 2023 Tipo del documento: Article

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