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Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.
Pratsinis, Anna; Fan, Yuchen; Portmann, Michaela; Hammel, Michal; Kou, Ponien; Sarode, Apoorva; Ringler, Philippe; Kovacik, Lubomir; Lauer, Matthias E; Lamerz, Jens; Hura, Greg L; Yen, Chun-Wan; Keller, Michael.
Afiliación
  • Pratsinis A; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Fan Y; Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Portmann M; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Hammel M; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Lab, Berkeley, CA, USA.
  • Kou P; Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sarode A; Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ringler P; Biozentrum, University of Basel, Spitalstrasse 41, CH - 4056 Basel, Switzerland.
  • Kovacik L; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Lauer ME; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Lamerz J; PD Data Sciences Nonclinical Biostatistics, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Hura GL; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Lab, Berkeley, CA, USA.
  • Yen CW; Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: yenc3@gene.com.
  • Keller M; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address: michael.keller.mk5@roche.com.
Int J Pharm ; 637: 122874, 2023 Apr 25.
Article en En | MEDLINE | ID: mdl-36948476

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas Idioma: En Revista: Int J Pharm Año: 2023 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas Idioma: En Revista: Int J Pharm Año: 2023 Tipo del documento: Article País de afiliación: Suiza