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CD3+CD56+ and CD3-CD56+ lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C.
de Almeida, Sergio M; Beltrame, Miriam Perlingeiro; Tang, Bin; Rotta, Indianara; Justus, Julie Lilian P; Schluga, Yara; da Rocha, Maria Tadeu; Martins, Edna; Liao, Antony; Abramson, Ian; Vaida, Florin; Schrier, Rachel; Ellis, Ronald J.
Afiliación
  • de Almeida SM; Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: sergio.ma@ufpr.br.
  • Beltrame MP; Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Tang B; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
  • Rotta I; Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Justus JLP; Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Schluga Y; Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • da Rocha MT; Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Martins E; Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Liao A; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
  • Abramson I; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
  • Vaida F; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
  • Schrier R; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
  • Ellis RJ; HIV Neurobehavioral Research Center (HNRC), UCSD, San Diego, CA, USA.
J Neuroimmunol ; 377: 578067, 2023 04 15.
Article en En | MEDLINE | ID: mdl-36965365
ABSTRACT
The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3+CD56+ and CD3-CD56dim is reduced in HIV-1C compared to HIV-1B due to the Tat C30S31 substitution in HIV-1C. 34 CSF and paired blood samples (PWH, n = 20; PWoH, n = 14) were studied. In PWH, the percentage of CD3+CD56+ was higher in CSF than in blood (p < 0.001), comparable in both compartments in PWoH (p = 0.20). The proportion of CD3-CD56dim in CSF in PWH was higher than PWoH (p = 0.008). There was no subtype differences. These results showed CNS compartmentalization of NKT cell response in PWH.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Células T Asesinas Naturales Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Células T Asesinas Naturales Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article