Enhanced fitness of SARS-CoV-2 B.1.617.2 Delta variant in ferrets.
Virology
; 582: 57-61, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-37028126
ABSTRACT
Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant displaced the prototype Washington/1/2020 (WA/1) strain. While WA/1 virus exhibited a moderately increased proportion compared to that in the inoculum following co-infection in human respiratory cells, Delta variant possessed a substantial in vivo fitness advantage as this virus becoming predominant in both inoculated and contact animals. This work identifies critical traits of the Delta variant that likely played a role in it becoming a dominant variant and highlights the necessities of employing multiple model systems to assess the fitness of newly emerged SARS-CoV-2 variants.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hurones
/
COVID-19
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Virology
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos