A fully automated micro­CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.

Buccardi, Martina; Ferrini, Erica; Pennati, Francesca; Vincenzi, Elena; Ledda, Roberta Eufrasia; Grandi, Andrea; Buseghin, Davide; Villetti, Gino; Sverzellati, Nicola; Aliverti, Andrea; Stellari, Franco Fabio

A fully automated microCT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.

Buccardi, Martina; Ferrini, Erica; Pennati, Francesca; Vincenzi, Elena; Ledda, Roberta Eufrasia; Grandi, Andrea; Buseghin, Davide; Villetti, Gino; Sverzellati, Nicola; Aliverti, Andrea; Stellari, Franco Fabio.

Afiliación

Buccardi M; Department of Mathematical, Physical and Computer Sciences, University of Parma, Parma, Italy.
Ferrini E; Experimental Pharmacology & Translational Science Department, Chiesi Farmaceutici S.P.A, 43122, Parma, Italy.
Pennati F; Department of Veterinary Science, University of Parma, Parma, Italy.
Vincenzi E; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico Di Milano, Milan, Italy.
Ledda RE; Department of Computer Science, Bioengineering, Robotics and Systems Engineering, University of Genoa, Genoa, Italy.
Grandi A; Camelot Biomedical System S.R.L, Via Al Ponte Reale 2/20, 16124, Genoa, Italy.
Buseghin D; Department of Medicine and Surgery, University of Parma, Parma, Italy.
Villetti G; Experimental Pharmacology & Translational Science Department, Chiesi Farmaceutici S.P.A, 43122, Parma, Italy.
Sverzellati N; Department of Medicine and Surgery, University of Parma, Parma, Italy.
Aliverti A; Experimental Pharmacology & Translational Science Department, Chiesi Farmaceutici S.P.A, 43122, Parma, Italy.
Stellari FF; Department of Medicine and Surgery, University of Parma, Parma, Italy.

Respir Res ; 24(1): 126, 2023 May 09.

Article en En | MEDLINE | ID: mdl-37161569

Asunto(s)

Aprendizaje Profundo; Fibrosis Pulmonar; Animales; Humanos; Ratones; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/diagnóstico por imagen; Fibrosis Pulmonar/tratamiento farmacológico; Microtomografía por Rayos X; Reproducibilidad de los Resultados; Bleomicina/toxicidad; Modelos Animales de Enfermedad

Palabras clave

Bleomycin model; Deep learning; Drug discovery; Lung fibrosis; Micro-computed tomography

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Aprendizaje Profundo Tipo de estudio: Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Respir Res Año: 2023 Tipo del documento: Article País de afiliación: Italia

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